Three Kryptonian villains from the Phantom Zone escape and expose Superman to Red Kryptonite causing him to age rapidly. The rest of the Super Friends get trapped by the villains and must now escape from the Phantom Zone. Meanwhile, the Justice League Computer tells Superman the only possible antidote for his rapid aging is Blue Kryptonite. Since Blue Kryptonite is harmful to Bizarro it may have an opposite effect on Superman since he reacts differently to Bizarro in many ways. Superman must take the Supermobile to go to the site where Krypton blew up and get the Blue Kryptonite in time and save his Super Friends to help him send the Kryptonian villains back to the Phantom Zone.