A scientist named Dr. Contra is working with anti-matter. An accident occurs and Dr. Contra is transformed into the Anti-matter Man. The scientists at the research center call Space Ghost for help. Space Ghost, Jace, Jan, and Blip take the doctor to Omicron in the Phantom Cruiser. They are searching for an anti-matter reversing ray. On the way the doctor's evil side takes over and tries to destroy Space Ghost and the twins. They travel through an ion cloud that cures Dr. Contra of his anti-matter personality.
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