Keith (Bill Hader) writes a letter to his sister, as Dave (Andy Samberg) asks what he is doing. As Keith responds, explaining he hasn't seen his sister in a long time, Dave suddenly and inexplicably shoots him. In the following overly dramatic, slow-motion death overdubbed by a cue of "Hide and Seek" by Imogen Heap, Dave is seen visibly shaken as Keith, in shock, collapses. As Dave gathers his bearings, Keith suddenly shoots him in return, having recovered from his injury long enough to exact his revenge to the same music cue.
After both men have fallen to the ground from their separate shootings, another man, Eric (Shia LaBeouf), enters looking for them (saying he's "just thought of the funniest thing"). Dave comes back to life to shoot Eric in the stomach, who collapses, once again to the same music. The sister herself (Kristen Wiig) enters the scene, and begins to read the letter (Dear Sister, By the time you read this..) until she too is shot in the gut several times by each of the three men on the ground, with the music cue restarting with every shot, until she collapses too.
The short ends as two police officers (Jason Sudeikis, Fred Armisen) are observing the crime scene. One finds the letter, left on the table near the brother's body, and begins to read. The letter is revealed to be a prediction of each shooting, in detail, and ends claiming that two police officers will come across the letter and then shoot each other after reading it. While the reading officer laughs it off, his partner turns and shoots him as the reading officer shoots him as well to overlapping "Hide & Seek" cues.