During the 1920s, three New York girls pursue careers performing in the iconic Ziegfeld Follies. Susan (Judy Garland) is a vaudeville performer who desires nothing more than a shot at the big time. Sheila (Lana Turner), who works as an elevator girl, is granted an audition with Flo Ziegfeld himself. And Sandra (Hedy Lamarr) draws the eye of a dance director after her husband auditions for a position in the orchestra. However, their career ambitions soon complicate their romantic relationships.