After graduating from medical school, Dr. James Kildare (Lew Ayres) travels to Connecticut to visit his father (Samuel S. Hinds), mother (Emma Dunn) and girlfriend (Lynne Carver). Despite his family's wishes, Dr. Kildare chooses to pursue a paid internship at Blair General Hospital in New York City. There, he meets Dr. Leonard Gillespie (Lionel Barrymore), a skilled, no-nonsense physician who begins mentoring him. However, Dr. Kildare soon learns that Dr. Gillespie is terminally ill.
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