A woman suffering from dissociative personality disorder uses her $80-million lottery windfall to produce a cable-access talk show dedicated to examining her life and relationships. Alice Klieg (Kristen Wiig) is an obsessive Oprah fan who manages her acute mental illness with a strict regimen of medications, a carefully monitored protein diet, and sessions with her perceptive therapist (Tim Robbins). Every day is a struggle for Alice, as evidenced in her failed marriage and her strained relationship with her elderly, perpetually exacerbated parents. Alice is also obsessed with fame, so upon winning $80 million in the state lottery, she goes off her meds, quits therapy, moves into a luxury suite in a Las Vegas casino, and pitches a talk-show idea to a local public-access cable producer (James Marsden), whose company is quickly running out of cash. Titled "Welcome to Me," the program offers Alice a platform to explore past emotional traumas in addition to featuring the occasional cooking segment. Although the show begins to develop a curious cult following, it also begins to isolate Alice from everyone in her life, including her once-loyal best friend (Linda Cardellini). Later, with her personal relationships in shambles, Alice begins steering the focus of "Welcome to Me" in a disturbing and completely unexpected direction, prompting even her most loyal viewers to question their reason for watching. Joan Cusack, Jennifer Jason Leigh, and Wes Bentley co-star in a film produced by Will Ferrell and Adam McKay.