From the late 19th century into the 20th century, an area of New York City nicknamed Tin Pan Alley was the heart of the American popular music scene. In this hotbed of creativity, singing sisters Katie (Alice Faye) and Lily Blane (Betty Grable) team up with musicians Harry Calhoun (Jack Oakie) and Skeets Harrigan (John Payne) to find their fame and fortune. Romance soon follows, but the rocky road to success and the looming World War I threaten to tear the couples apart.
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