Fabric designer Harry Quincey (George Sanders) has the unhappy task of caring for his tiresome unmarried sisters, Lettie (Geraldine Fitzgerald) and Hester (Moyna MacGill). When Harry falls in love with Deborah Brown (Ella Raines), Hester is delighted, but Lettie smolders with jealousy. Upset at Lettie 's opposition, Harry would like nothing better than to do her in. Does he? And what has really happened here? When originally presented on Broadway, Thomas Job's play +Uncle Harry utilized a complex flashback technique in unfolding its story, which was capped by a grimly ironic ending. Stephen Longstreet's screenplay not only takes a more linear approach, but also radically alters the ending to conform with the censorship strictures then in effect. The Strange Affair of Uncle Harry was one of several Universal film noirs of the 1940s produced by longtime Alfred Hitchcock associate Joan Harrison.