Following many years of estrangement, twins Milo (Bill Hader) and Maggie (Kristen Wiig) have an unexpected reunion after a set of near-tragedies. The situation forces them to confront how their lives became so broken. For Maggie, it means examining why she's so unhappy in a marriage to a loving husband. For Milo, it means meeting with his first love to see if their romance can reignite. Eventually, they learn that living truthfully and accepting each other is the only way to move forward.