Government agent Gene Autry (Gene Autry) and his faithful partner, Frog Millhouse (Smiley Burnette), are sent to a small town to uncover the cause of a rash of deaths among the local cattle herds. When the townspeople turn to outdated methods in their quest to eradicate the culprit, a deadly and fast-growing plant, Autry suggests crop dusting. As Autry struggles to convince angry skeptics of the value and efficiency of pesticides, he falls for lovely local Sue Larrabee (Fay McKenzie).
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