In the mid-21st century, an epidemic of organ failures leads to the rise of GeneCo., a company providing transplants at a great price. Those who miss their payments become targets of GeneCo. mercenaries, who repossess the organs. In a world of drug addiction and legalized murder, a sheltered youth (Alexa Vega) seeks a cure for her rare disease as well as information about her family's mysterious history. Her questions are answered at "The Genetic Opera."