At the Brentwood Asylum for the mentally ill, psychiatrist partners Jane Everest (Claudette Colbert) and Alex MacGregor (Joel McCrea) are broken up by the new superintendent, Dr. Charles Monet (Charles Boyer), who has a low regard for women physicians. Jane and Charles clash on patient treatment, and Jane learns that Charles has a sister, Claire (Helen Vinson), with a mysterious past. Frustrated by the situation at work, Alex begins treating Claire, despite the concerns of his wife.
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