The title character in Republic's Prison Nurse is a "woman in white" named Judy, played by Marian Marsh. Together with her friend Pepper (Bernardine Hayes), Judy hires on at a maximum-security prison smack dab in the middle of flood country. When she's not braving the elements and fending off the advances of the convicts, Judy is doing her best to contend with a raging typhoid epidemic. Henry Wilcoxon is integrity personified as the doctor who eventually falls in love with the dedicated heroine. Prison Nurse was one of four inexpensive Republic programmers directed by James Cruze, formerly one of the top filmmakers of the silent screen.