When an outbreak threatens the passengers aboard the S.S. Arcturus, engineer Crusher McKay (Victor McLaglen) and doctor Tony Craig (Chester Morris) set about to stop it, at the same time vying for the affections of nurse Ann Grayson (Wendy Barrie). As the cholera seizing the ship spreads to the crew and begins affecting Crusher, the mood on board becomes increasingly desperate. Soon both men realize they must find a way to put aside their differences to see to it that the ship makes it ashore.
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