Science goes too far as one of the greatest villains of the 20th century makes a last stand in South America in this crackpot thriller. After government scientists develop a new and virulent variety of nerve gas, Professor John Coleman (John Holland) sets out to create an antidote until he mysteriously disappears. Coleman's daughter Kathy (Audrey Caire) and her husband, Phil Day (Walter Stocker), who works in U.S. intelligence, begin to suspect foul play; they're approached by a man named Teo (Carlos Rivas) who is trying to tell them about the professor and a strange place called Mandoras when he's suddenly shot to death. With no other clues to follow, Kathy and Phil travel to the tiny Latin American nation of Mandoras, where Kathy happens to meet her hepcat sister, Suzanne (Dani Lynn), at a nightclub. Suzanne tells Kathy and Phil that she and the professor had been kidnapped, and when they're introduced to Teo's brother Camino (also played by Rivas), they learn of a bizarre plot. According to Camino, scientists in a secret lab on Mandoras have kept the disembodied head of Adolf Hitler (Bill Freed) alive in a jar, and under the orders of "Mr. H" they're engaged in a deadly scheme to take over the world and resurrect the Third Reich. The film Madmen of Mandoras received a brief theatrical release in 1963; later, when it was sold to television, the movie (running a brief 74 minutes) was padded with additional sequences, reported shot by a group of film students, that feature a completely different cast and don't at all resemble the shadowy visual style of the original movie. The strange variant television cut of the film gained a cult following under its title, They Saved Hitler's Brain.