After Alpha (Margaret O'Brien) is left at an orphanage as an infant, she's adopted by three professors who control her environment and transform her into a child genius. Years later, Alpha is exposed to outsiders for the first time when reporter Mike Regan (James Craig) is invited to interview her for a story. Taking pity on the girl, Mike helps her escape, and the two embark on an adventure across New York City. Along the way, they begin to form a father-daughter relationship.
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