In this farcical comedy, Renato (Pere Ponce) is a gay man who meets Ginevra (Claudia Gerini), a member of a lesbian rock band, at a friend's wedding. The two get along well, and when Renato's grandmother tells him, as her dying wish, that she'd like him to have sex with a woman just once so he would know what he's missing, he feels honor bound to try it -- and figures that Ginevra would be the best woman to ask. To their mutual surprise, Ginevra and Renato quite enjoy the experience, and they soon find that they have a lot of explaining to do to their respective significant others, Elisa (Ana Risueno) and Francesco (Paolo Sassanelli). La Vespa e la Regina was the debut feature for director Antonello De Leo.
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