Chromosome X clashes with Chromosome Y in Michael Andre and Nikka Kalashnikova's acidic road movie concerning a female artist's encounter with an unpredictable lone male. As the artist (Kalashnikova) makes her way down the interstate en route to her first solo exhibit, a man (Andre) with a video camera pulls up alongside her and points his lens in her direction. In the thrill of the moment, the artist reacts by sexually taunting the camera happy driver. This response sends the man into a frenzy, and he repeatedly begins ramming her car. Strangely, all the woman can do is laugh at this potentially violent development. As the encounter continues, the sexual psychosis of the male gender becomes increasingly pronounced and the situation quickly spins out of control.