Cattle ranchers Belknap (Walter Miller) and Selby (Gordon Hart) plot to send their cattle to market before agricultural inspector Gene Autry (Gene Autry) can confirm the presence of hoof-and-mouth disease. Learning a veterinarian is also on the way to inspect, Belknap and Selby move their infected cattle to the ranch of unsuspecting Jim Wheeler (George Cleveland) and his daughter (June Storey). Suspicious, Gene and his partner, Frog (Smiley Burnette), investigate and unearth a complex plot.
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