Henry (Michael Rooker) is released from prison following his mother's murder. He supplements his job as an exterminator with a series of indiscriminate and violent murders. Fellow jailbird and drug dealer Otis (Tom Towles) becomes a willing accomplice in Henry's bloody killings. But as the depravity escalates and Henry forms a bond with Otis' sister, Becky (Tracy Arnold), things start to get out of hand. The film is based on the true-life story of serial killer Henry Lee Lucas.