Gene (Gene Autry) and his sidekick, Frog (Smiley Burnette), learn that a band of crooks is trying to illegally transport cattle carrying a contagious disease. Gene and Frog alert the sheriff of a nearby town, but the crooks then kill the lawman and try to pin the murder on Gene. Luckily, with the help of the dead man's daughter, Marjorie (Dorothy Dix), Gene clears his name and takes over as the new sheriff. He and Frog then set out to bring the outlaws to justice.
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