When his father's ranch faces foreclosure, cowboy Ross McEwen (Joel McCrea) sets out to rob a bank. Leaving an IOU after committing the crime, McEwen makes a successful escape via train, though a rattlesnake bites him in the process. Fortunately for McEwen, nurse Fay Hollister (Frances Dee) is on board to save his life. However, McEwen is far from free and clear, since Sheriff Pat Garrett (Charles Bickford) is hot on his trail. With a reward on his head, McEwen must be careful whom he trusts.