John Crowley (Brendan Fraser) is a man on the corporate fast-track, with a beautiful wife (Keri Russell) and three children. Just as his career is taking off, he learns that his two youngest kids have a fatal disease. John leaves his job and devotes himself to saving their lives. He joins forces with Dr. Robert Stonehill (Harrison Ford), a brilliant but eccentric scientist. Together they battle the medical and corporate establishment, racing against time for a cure.