Florence Lawrence, the motion-picture industry's first real movie star, was at the tail end of her popularity when she appeared in Elusive Isabel. Lawrence plays a seductive secret agent for an unnamed Latin nation. Her mission is to clear the path for a takeover of the U.S., engineered by the combined South American powers (the film was made at a time when the U.S. and Mexico were at serious odds with one another). She is deflected from her purpose by American spy Hamilton Grimm (Harry Millarde). Elusive Isabel was based on a jingoistic "preparedness" novel by Jacques Futrelle.
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