Terence McDonagh (Nicolas Cage) isn't doing so well. He has a nasty painkiller addiction, courtesy of an injury he sustained while rescuing a prisoner during Hurricane Katrina. Plus, there's his alcoholic father (Tom Bower), boozy wife (Jennifer Coolidge) and prostitute girlfriend (Eva Mendes). And, he's just been saddled with a rookie partner (Shawn Hatosy). Now Terence must pull himself back from the edge of insanity to investigate a series of murders that has the city on edge.